Professor Andrew Clegg

Head of Academic Unit for Ageing and Stroke Research and Theme Lead for Health and Care in our Ageing Society theme

Professor Andrew Clegg is Theme Lead for the Health and Care in our Ageing Society theme.

He is also Head of Ageing and Stroke Research at the University of Leeds and an Honorary Consultant Geriatrician at Bradford Royal Infirmary. Professor Clegg is Director of the global Ageing Research Trialist (ART) Collaborative, which was established to support individual participant data meta-analyses in ageing research, and Co-Director of Health Data Research UK (HDR UK) North.

Professor Clegg leads a substantial portfolio of ageing-related research, with a particular focus on frailty as a complex and problematic expression of multimorbidity in later life, as well as medicines optimisation. He has secured approximately £44 million in research funding as lead or co-investigator. This includes leadership of a research theme focused on improving care for older people with frailty within the NIHR Applied Research Collaboration Yorkshire and Humber, and a workstream within the NIHR Leeds Biomedical Research Centre (BRC) Musculoskeletal Theme.

His research expertise spans clinical trials of interventions, prognostic modelling using routine data, applied epidemiology, and evidence synthesis. He is Chief Investigator for the NIHR-funded Personalised Care Planning for Older People with Frailty (PROSPER) Research Programme, the Community Ageing Research 75+ study, and the Wellbeing in Later Life in Bradford longitudinal cohort study with routine data linkage. He is also Co-Chief Investigator for the NIHR HTA-funded Comprehensive Geriatric Assessment for Older People with Heart Failure and Frailty (CHART) trial.

Professor Clegg previously led the development, validation, and national implementation of the multi-award-winning electronic frailty index (eFI), which is recommended in the NICE Multimorbidity Guideline. Developed using data from approximately one million UK patients within the ResearchOne and THIN primary care research databases, the eFI has had a significant impact on UK health policy and was selected as a National Medical Schools Council Impact Case Exemplar in 2022.

Professor Andrew Clegg's latest projects

The INCLUDE study: Development of methods to identify digitally excluded older people, and tailoring of interventions to meet their digital needs

Background Older people are more likely to be ‘digitally excluded’. This refers to them not using the internet, so missing out on things that could be helpful to their well-being...

Development and national implementation of eFI-2

Currently, the UK and international guidelines support routine identification of frailty in primary care to enable timely and targeted care for older people. Our Older people with Frailty theme lead,...

Cross-ARC expansion of CARE75+ cohort study

The Community Ageing Research (CARE75+) Study is a longitudinal cohort study that recruits older people (≥ 75 years) via General Practices across England. The study is hosted at Bradford Teaching...

Professor Andrew Clegg's latest publications

Home-Based Extended Rehabilitation for Older People with Frailty (HERO): A Randomised Controlled Trial

Home-Based Extended Rehabilitation For Older People With Frailty (HERO): A Multicentre Randomised Controlled Trial with Health Economic Analysis and Process Evaluation

Developing an AI-Assisted Tool That Identifies Patients With Multimorbidity and Complex Polypharmacy to Improve the Process of Medication Reviews: Qualitative Interview and Focus Group Study

An automation framework for clinical codelist development validated with UK data from patients with multiple long-term conditions

Differences in the risk of frailty based on care receipt, unmet care needs and socio-economic inequalities: A longitudinal analysis of the English Longitudinal Study of Ageing

Primary care prediction of hip and knee replacement 1–5 years in advance using Temporal Graph-based Convolutional Neural Networks (TG-CNNs)

Other Team members

Dr Jamilla Hussain

Co-Deputy Lead for Health and Care in our Ageing Society theme and YH ARC Research Inclusion lead

Professor Andrew Clegg

Head of Academic Unit for Ageing and Stroke Research and Theme Lead for Health and Care in our Ageing Society theme

Lesley Brown

Theme Manager