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Professor Andrew Clegg

Head of Academic Unit for Ageing and Stroke Research, NIHR Research Professor of Geriatric Medicine

Andy is NIHR Research Professor of Geriatric Medicine, Head of Ageing and Stroke Research at the University of Leeds and Honorary Consultant Geriatrician at Bradford Royal Infirmary. He is Director of the global Ageing Research Trialist (ART) collaborative, established to support individual participant data meta-analysis in ageing research, and Co-Director for Health Data Research UK (HDRUK) in the North of England.

Andy leads a large portfolio of ageing-related research, with a focus on frailty as an especially problematic expression of multimorbidity in later life, and medicines optimisation. He holds research grants of around £44M as lead or co-investigator, including as Co-Director of the NIHR Applied Research Collaboration in the Yorkshire & Humber region of England, and a workstream within the NIHR Leeds Biomedical Research Centre (BRC) Musculoskeletal Theme. Research expertise spans clinical trials of interventions, prognostic modelling using routine data, applied epidemiology and advanced evidence synthesis.

Andy previously led the development, validation and national implementation of the multi award-winning and NICE Guideline-recommended electronic frailty index (eFI) using routine Electronic Patient Record (EPR) data from around 1M UK patients. This work has had major impact on UK health policy, and influence on international research practice, including in the US. More recently, Andy led the development of eFI2 using novel prediction modelling methods, and led the development and external validation of the first international falls prediction model using routine EPR data. He is also leading work to develop, validate and implement the Anticholinergic Medication Index as a measure of anticholinergic medication burden suitable for deployment within UK and international EPR systems.

Professor Andrew Clegg's latest projects

The INCLUDE study: Development of methods to identify digitally excluded older people, and tailoring of interventions to meet their digital needs

Background Older people are more likely to be ‘digitally excluded’. This refers to them not using the internet, so missing out on things that could be helpful to their well-being...

Development and national implementation of eFI-2

Currently, the UK and international guidelines support routine identification of frailty in primary care to enable timely and targeted care for older people. Our Older people with Frailty theme lead,...

Cross-ARC expansion of CARE75+ cohort study

The Community Ageing Research (CARE75+) Study is a longitudinal cohort study that recruits older people (≥ 75 years) via General Practices across England. The study is hosted at Bradford Teaching...

Professor Andrew Clegg's latest publications

Home-Based Extended Rehabilitation for Older People with Frailty (HERO): A Randomised Controlled Trial

Home-Based Extended Rehabilitation For Older People With Frailty (HERO): A Multicentre Randomised Controlled Trial with Health Economic Analysis and Process Evaluation

Developing an AI-Assisted Tool That Identifies Patients With Multimorbidity and Complex Polypharmacy to Improve the Process of Medication Reviews: Qualitative Interview and Focus Group Study

An automation framework for clinical codelist development validated with UK data from patients with multiple long-term conditions

Differences in the risk of frailty based on care receipt, unmet care needs and socio-economic inequalities: A longitudinal analysis of the English Longitudinal Study of Ageing

Primary care prediction of hip and knee replacement 1–5 years in advance using Temporal Graph-based Convolutional Neural Networks (TG-CNNs)

Other Team members

Professor Andrew Clegg

Head of Academic Unit for Ageing and Stroke Research, NIHR Research Professor of Geriatric Medicine

Lesley Brown

Theme Manager